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Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine

Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4+ T cells. We had previously shown that intranodal vaccination with class I neoantigen pep...

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Principais autores: Shinji Morisaki, Hideya Onishi, Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Sachiko Yoshimura, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Masafumi Nakamura, Takanari Kitazono, Takashi Morisaki
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-10-01
Serier:Frontiers in Immunology
Fag:
neoantigen
neoepitope
dendritic cell
vaccine
antigen presentation
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223331/full
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