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AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

Abstract To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels. Ca2+ nanodomains near store-operated Orai1 channels stimulate the protein phosphatase calc...

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Principais autores: Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2021-01-01
Serier:Function
Fag:
Store-operated calcium channels
calcium nanodomain
AKAP79
cyclic AMP
phosphodiesterase
adenylyl cyclase 8
Online adgang:https://journals.physiology.org/doi/10.1093/function/zqab036
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