Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants

Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease caused by genetic variants in sarcomeric proteins, particularly in myosin binding protein C3 (MYBPC3) and myosin heavy chain 7 (MYH7). Less known is that neonatal forms of HCM rapidly evolve into systolic heart failure and death with...

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Principais autores:	Tatiana Flisikowska, Björn Petersen, Giulia Mearini, Daniela Huber, Mayuko Kurome, Melanie Stoff, Saskia Schlossarek, Andrea Lucas-Hahn, Eckhard Wolf, Judith Montag, Angelika Schnieke, Lucie Carrier
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-06-01
Series:	Journal of Molecular and Cellular Cardiology Plus
Assuntos:	Base editing CRISPR/Cas9 Gene editing Hypertrophic cardiomyopathy MYBPC3 MYH7
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S277297612500176X
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