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Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway

Objective This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. Methods The expression pattern of Dvl3 was examined by IHC, WB, and qPCR. Modified exosomes obtained from culturing supernatant of RA-FLS infected with Dvl3 over expression (OE) lentiv...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Weixing Tan, Ning Chen, Yang Qiu, Xiaomei Feng, Shuwen Li, Yongjin Zhang, Haoran Li, Jie Gao, Dongbao Zhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2022-07-01
Schriftenreihe:Autoimmunity
Schlagworte:
ra-fls
dvl3
exosomes
wnt
inflammation
rhoa
rock2
Online-Zugang:http://dx.doi.org/10.1080/08916934.2022.2067984
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