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Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate

Abstract Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic clusters (IAHC) along with hematopoietic progenitors (HPC). The signalling mechanisms that distinguish HSCs from HPCs ar...

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Autores principales: Roshana Thambyrajah, Maria Maqueda, Wen Hao Neo, Kathleen Imbach, Yolanda Guillén, Daniela Grases, Zaki Fadlullah, Stefano Gambera, Francesca Matteini, Xiaonan Wang, Fernando J. Calero-Nieto, Manel Esteller, Maria Carolina Florian, Eduard Porta, Rui Benedito, Berthold Göttgens, Georges Lacaud, Lluis Espinosa, Anna Bigas
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2024-02-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-024-45716-y
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