Cerebrospinal fluid sTREM2 mediates the associations of α-synuclein with tau pathology in older adults without dementia: two population-based study

Abstract Background The role of microglial activation by α-synuclein in Alzheimer’s disease (AD) remains unclear. This study aimed to evaluate the role of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in regulating the relationship between α-synuclein and tau pathology in cerebro...

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Hauptverfasser:	Yong-Chang Wang, Liang-Yu Huang, Yan-Fu, Shi-Yin Xiong, Zuo-Teng Wang, Chen-Chen Tan, Lan Tan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-07-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Alzheimer’s disease Α-synuclein sTREM2 Microglia APOE ε4 Tau pathology
Online-Zugang:	https://doi.org/10.1186/s12967-025-06729-3
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