An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer

Abstract Background Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-cancer effects, but the action mechanisms are still unclear. Method MTT...

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Автори:	Guan-Yu Ruan, Li-Xiang Ye, Jian-Song Lin, Hong-Yu Lin, Li-Rui Yu, Cheng-Yan Wang, Xiao-Dan Mao, Shui-Hua Zhang, Peng-Ming Sun
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2023-03-01
Серія:	Journal of Translational Medicine
Предмети:	Kaempferol Human endometrial cancer HSD17B1 Estrogen receptor α Nude mice
Онлайн доступ:	https://doi.org/10.1186/s12967-023-04048-z
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