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Functional annotation of the Hippo pathway somatic mutations in human cancers

Abstract The Hippo pathway is commonly altered in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development remains unclear. Here we analyze the Hippo somatic mutations in the human cancer genome and functionally annotate their role...

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Autori principali: Han Han, Zhen Huang, Congsheng Xu, Gayoung Seo, Jeongmin An, Bing Yang, Yuhan Liu, Tian Lan, Jiachen Yan, Shanshan Ren, Yue Xu, Di Xiao, Jonathan K. Yan, Claire Ahn, Dmitry A. Fishman, Zhipeng Meng, Kun-Liang Guan, Ruxi Qi, Ray Luo, Wenqi Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-11-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-024-54480-y
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