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Piceatannol-3′-O-β-d-glucopyranoside mitigates myocardial ischemia-reperfusion injury by inhibiting ferroptosis through the regulation of NDUFS1 lactylation via metabolic reprogramming

Myocardial ischemia-reperfusion injury (MIRI) is a key factor affecting the prognosis of myocardial infarction patients. Currently, there remains a lack of specific drugs targeting MIRI, and it is unclear whether Piceatannol-3′-O-β-d-glucopyranoside (PG) improves MIRI through metabolic reprogramming...

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Principais autores: Genhao Fan, Chidao Zhang, Wenqing Zhang, Xuli Ji, Menglin Liu, Peng Chen, Boyong Qiu, Yankun Song, Min Zhang, Teng Ma, Zhengwei Dong, Zuoying Xing, Yuhong Huang, Mingjun Zhu, Yongxia Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-07-01
coleção:Redox Biology
Assuntos:
Piceatannol-3′-O-β-d-glucopyranoside
Lactylation
MIRI
Ferroptosis
Metabolic reprogramming
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231726001965
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