Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity

Abstract Flagellin, the TLR5 agonist, shows potent adjuvant activities in diverse vaccines and immunotherapies. Vibrio vulnificus flagellin B expressed in eukaryotic cells (eFlaB) could not stimulate TLR5 signaling. Enzymatic deglycosylation restored eFlaB’s TLR5 stimulating functionality, suggestin...

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Bibliografiske detaljer

Principais autores:	Koemchhoy Khim, Sao Puth, Kamalakannan Radhakrishnan, Tien Duc Nguyen, Youn Suhk Lee, Che-Hun Jung, Shee Eun Lee, Joon Haeng Rhee
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2023-09-01
Serier:	npj Vaccines
Online adgang:	https://doi.org/10.1038/s41541-023-00738-3
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