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Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

Genetic polymorphism in the interferon lambda (IFN-λ) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-λ polymorphism and HCV variation in 8729 patients (Europeans 77%, Asians 1...

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Hoofdauteurs: Nimisha Chaturvedi, Evguenia S Svarovskaia, Hongmei Mo, Anu O Osinusi, Diana M Brainard, G Mani Subramanian, John G McHutchison, Stefan Zeuzem, Jacques Fellay
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications Ltd 2019-09-01
Reeks:eLife
Onderwerpen:
genome to genome analysis
Hepatitis C
interferon lambda polymorphism
integration analysis
Online toegang:https://elifesciences.org/articles/42542
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