Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region
AA amyloidosis is the result of overproduction and aberrant processing of acute-phase serum amyloid A1 (SAA1) by hepatocytes. Proteolytic cleavage of SAA1 is believed to play a central role in AA amyloid formation. The SAA1 protein undergoes a cleavage of 18 residues consisting of the signal peptide...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2022-09-01
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| Serie: | Biochemistry and Biophysics Reports |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S240558082200084X |
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