Structural and molecular characterization of lopinavir and ivermectin as breast cancer resistance protein (BCRP/ABCG2) inhibitors

A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a promising approach to overcome the resistance...

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Hlavní autoři:	Julia de Paula Dutra, Gustavo Scheiffer, Thales Kronenberger, Lucas Julian Cruz Gomes, Isadora Zanzarini, Kelly Karoline dos Santos, Arun K. Tonduru, Antti Poso, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2023-11-01
Edice:	EXCLI Journal : Experimental and Clinical Sciences
Témata:	abcg2 drug repositioning lopinavir ivermectin molecular modelling
On-line přístup:	https://www.excli.de/index.php/excli/article/view/6427
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