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The potential of PARP as a therapeutic target across pediatric solid malignancies

Abstract Background Pediatric cancer is the leading cause of disease-related death in children and the need for better therapeutic options remains urgent. Due to the limited number of patients, target and drug development for pediatrics is often supplemented by data from studies focused on adult can...

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Autori principali: Kaylee M. Keller, Joost Koetsier, Linda Schild, Vicky Amo-Addae, Selma Eising, Kim van den Handel, Kimberley Ober, Bianca Koopmans, Anke Essing, Marlinde L. van den Boogaard, Karin P. S. Langenberg, Natalie Jäger, Marcel Kool, Stefan Pfister, M. Emmy M. Dolman, Jan J. Molenaar, Sander R. van Hooff
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-04-01
Serie:BMC Cancer
Soggetti:
PARP
Pediatric cancer
Synergy
Replication stress
Ribosomes
DNA damage
Accesso online:https://doi.org/10.1186/s12885-022-10319-7
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