Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding

SutA is a transcription factor which increases transcription activity of an RNA polymerase (RNAP). Here, authors present cryo-EM structures of SutA-bound RNAP-σS holoenzyme and SutA-bound transcription initiation complex, which reveals SutA wedging the RNAP-β lobe open to aid unwinding.

Detalhes bibliográficos

Principais autores:	Dingwei He, Linlin You, Xiaoxian Wu, Jing Shi, Aijia Wen, Zhi Yan, Wenhui Mu, Chengli Fang, Yu Feng, Yu Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-07-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-022-31871-7
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