Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

<p>Abstract</p> <p>Background</p> <p>Mice with peroxisome deficiency in neural cells (<it>Nestin-Pex5</it>^{<it>−/−</it>}<it>)</it> develop a neurodegenerative phenotype leading to motor and cognitive disabilities and early death. Major pathologies at the end stage of disease include severe...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Bottelbergs Astrid, Verheijden Simon, Van Veldhoven Paul P, Just Wilhelm, Devos Rita, Baes Myriam
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2012-03-01
Цуврал:	Journal of Neuroinflammation
Нөхцлүүд:	Peroxisomes Mouse models Plasmalogens Complement Demyelination Axonal degeneration Inflammation Macrophage
Онлайн хандалт:	http://www.jneuroinflammation.com/content/9/1/61
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!