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Biological and prognostic relevance of A-to-I RNA editing across consensus molecular subtypes of colon cancer

Abstract Colorectal cancer (CRC) is the second most frequently diagnosed cancer worldwide and represents a major challenge for public health. Despite advances in molecular profiling, important gaps remain in our understanding of tumorigenesis and the regulatory mechanisms underlying CRC progression....

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Principais autores: Dario Monaco, Debora Traversa, Eliseo Mattioli, Francesco Alfredo Zito, Grazia Cristiani, Francesca Buono, Sabina Delcuratolo, Tiziana Guarino, Rosamaria Pinto, Antonia Lasorella, Rosanna Lacalamita, Ernesto Picardi, Stefania Tommasi, Simona De Summa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-01-01
coleção:Scientific Reports
Assuntos:
RNA editing
ADAR enzymes
Consensus molecular subtypes (CMS)
CeRNA network tumor microenvironment (TME)
Survival analysis
Chemoresistance
Acesso em linha:https://doi.org/10.1038/s41598-025-34043-x
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