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Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells

Abstract Targeted therapy remains the future of anti‐cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical potential, and are currently being evaluated in the...

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Главные авторы: Francis M. Barnieh, Goreti Ribeiro Morais, Paul M. Loadman, Robert A. Falconer, Sherif F. El‐Khamisy
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley 2024-09-01
Серии:Advanced Science
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Online-ссылка:https://doi.org/10.1002/advs.202403831
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