AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA)1 binds with high affinity to the BB1R...

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Principais autores:	Terry W. Moody, Nicole Tashakkori, Samuel A. Mantey, Paola Moreno, Irene Ramos-Alvarez, Marcello Leopoldo, Robert T. Jensen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-07-01
coleção:	Frontiers in Endocrinology
Assuntos:	small molecule antagonists GRPR NMBR bombesin receptor subtype-3 lung cancer
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fendo.2017.00176/full
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