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Resident Self-Tissue of Proinflammatory Cytokines Rather Than Their Systemic Levels Correlates with Development of Myelofibrosis in <i>Gata1</i><sup>low</sup> Mice

Serum levels of inflammatory cytokines are currently investigated as prognosis markers in myelofibrosis, the most severe Philadelphia-negative myeloproliferative neoplasm. We tested this hypothesis in the <i>Gata1</i><sup>low</sup> model of myelofibrosis. <i>Gata1</i><sup>low</sup> mice, and age-mat...

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Principais autores: Maria Zingariello, Paola Verachi, Francesca Gobbo, Fabrizio Martelli, Mario Falchi, Maria Mazzarini, Mauro Valeri, Giuseppe Sarli, Christian Marinaccio, Johanna Melo-Cardenas, John D. Crispino, Anna Rita Migliaccio
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-01-01
coleção:Biomolecules
Assuntos:
myelofibrosis
GATA1
proinflammatory cytokines
TGF-β1
interleukin 8
megakaryocytes
Acesso em linha:https://www.mdpi.com/2218-273X/12/2/234
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