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Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma

Abstract Background p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous cell carcinoma (HNSCC) cell death. Methods CAL-27 and SCC-25 c...

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Principais autores: Zhe Liu, Douglas R. Hurst, Xing Qu, Li-Guang Lu, Chen-Zhou Wu, Yu-Yu Li, Yi Li
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co., Ltd. 2020-10-01
coleção:Military Medical Research
Assuntos:
DIRAS3
p53
Apoptosis
Autophagy
Head and neck squamous cell carcinoma
Acesso em linha:http://link.springer.com/article/10.1186/s40779-020-00275-3
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