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Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis

Alveolar echinococcosis (AE) is caused by infection with the fox tapeworm E. multilocularis. The disease affects humans, dogs, captive monkeys, and other mammals, and it is caused by the metacestode stage of the parasite growing invasively in the liver. The current drug treatment is based on non-par...

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Principais autores: Roman Memedovski, Matías Preza, Joachim Müller, Tobias Kämpfer, Reto Rufener, Marcus Vinicius Nora de Souza, Emerson Teixeira da Silva, Gabriel Fernandes de Andrade, Sophie Braga, Anne-Christine Uldry, Natasha Buchs, Manfred Heller, Britta Lundström-Stadelmann
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-04-01
Serier:International Journal for Parasitology: Drugs and Drug Resistance
Fag:
Echinococcus multilocularis
Alveolar echinococcosis
Mefloquine
Structure-activity relationship (SAR)
Mode of action
nLC-MS/MS
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211320723000106
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