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Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants

The genetic architecture of late-onset Alzheimer disease (AD) in African Americans (AAs) differs from that in persons of European ancestry. In addition to APOE, genome-wide association studies (GWASs) of AD in AA samples have implicated ABCA7, COBL, and SLC10A2 as AA-AD risk genes. Previously, we id...

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Principais autores: Mark W. Logue, Daniel Lancour, John Farrell, Irina Simkina, M. Daniele Fallin, Kathryn L. Lunetta, Lindsay A. Farrer
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-08-01
Serier:Frontiers in Neuroscience
Fag:
Alzheimer disease
sequencing
AKAP9
ABCA7
rare variant
African Americans
Online adgang:https://www.frontiersin.org/article/10.3389/fnins.2018.00592/full
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