Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

Abstract Background Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key proteins that have been implicated in chronic muscle atrophy of several w...

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Detalhes bibliográficos

Principais autores:	Thanh Nguyen, T. Scott Bowen, Antje Augstein, Antje Schauer, Alexander Gasch, Axel Linke, Siegfried Labeit, Volker Adams
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-04-01
coleção:	Skeletal Muscle
Assuntos:	Cardiac cachexia Pulmonary hypertension Muscle atrophy Myofibrillar proteins MuRF1 and MuRF2 Muscle energy metabolism
Acesso em linha:	http://link.springer.com/article/10.1186/s13395-020-00229-2
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