Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Abstract Endotoxin-driven systemic immune activation is a common hallmark across various clinical conditions. During acute critical illness, elevated plasma lipopolysaccharide triggers non-specific systemic immune activation. In addition, a compositional shift in the gut microbiota, including an inc...

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Detalles Bibliográficos

Principais autores:	Sanne Kroon, Dejan Malcic, Lena Weidert, Lea Bircher, Leonardo Boldt, Philipp Christen, Patrick Kiefer, Anna Sintsova, Bidong D. Nguyen, Manja Barthel, Yves Steiger, Melanie Clerc, Mathias K.-M. Herzog, Carmen Chen, Ersin Gül, Benoit Guery, Emma Slack, Shinichi Sunagawa, Julia A. Vorholt, Lisa Maier, Christophe Lacroix, Annika Hausmann, Wolf-Dietrich Hardt
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-03-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-57979-0
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