Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2

Thiamine helps transketolase in removing toxic metabolites, counteracting high glucose-induced damage in microvascular cells, and progression of diabetic retinopathy/nephropathy in diabetic animals. Diabetic subjects show reduced thiamine levels. Hyperglycemia and reduced thiamine availability concu...

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Autores principales:	Aurora Mazzeo, Federica Barutta, Linda Bellucci, Marina Trento, Gabriella Gruden, Massimo Porta, Elena Beltramo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-04-01
Colección:	Biomedicines
Materias:	thiamine renal glomerular cells thiamine transporters diabetic nephropathy transketolase
Acceso en línea:	https://www.mdpi.com/2227-9059/9/4/385
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