Gut microbiota metabolites drive osteosarcoma progression through JUP activation: a multi-omics mendelian randomization study

Abstract Osteosarcoma exhibits high heterogeneity and lacks effective therapeutic targets. This study integrated Mendelian randomization, transcriptomics, and 16S rRNA sequencing to investigate potential associations between gut microbiota, metabolites, and osteosarcoma. Multi-omics analysis identif...

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Bibliografische Detailangaben

Hauptverfasser:	Qun Zhang, Tianran Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2026-04-01
Schriftenreihe:	AMB Express
Schlagworte:	Osteosarcoma Gut microbiota JUP Mendelian randomization Tumor microenvironment
Online-Zugang:	https://doi.org/10.1186/s13568-026-02056-y
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