Deciphering the NEK7-NLRP3 inflammasome assembly: from conformational activation to allosteric drug discovery

The NLRP3 inflammasome, a pivotal component of innate immunity, orchestrates immune defense and inflammatory responses. NEK7, an essential upstream regulator, drives inflammasome assembly through direct interaction with NLRP3. This review systematically summarizes the molecular mechanisms, upstream...

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Detalhes bibliográficos

Principais autores:	Chun-Ling Gu, Dong-Dong Liu, Hong Chen, Xiao-Hong Wei, Hong-Cai Shang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Immunology
Assuntos:	inflammasome inhibitors NEK7 NLRP3 inflammasome post-translational modification targeted therapy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1773422/full
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