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Integrative analysis of transcriptome and single-cell sequencing combined with experimental validation identifies biomarkers associated with T cell and senescence in sepsis

Abstract Sepsis is an infection-induced systemic inflammatory response syndrome. T cell remodeling and senescence are linked to sepsis, so identifying T cell-related genes (TCRGs) and senescence-related genes (SRGs) as biomarkers is crucial for elucidating mechanisms, diagnosis, and targeted therapy...

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Hlavní autoři: Kairui Yang, Yunlong Hu, Chunhui Ma, Jianing Wang, Yang Wang, Xuejie Han, Jiafeng Lv, Xiaolei Zhang, Yunliang Cui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2026-02-01
Edice:Scientific Reports
Témata:
Sepsis
T cell
Senescence
Transcriptome sequencing analysis
Biomarkers
On-line přístup:https://doi.org/10.1038/s41598-026-38559-8
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