shRNA-mediated downregulation of α-N-Acetylgalactosaminidase inhibits migration and invasion of cancer cell lines

Objective(s): Extracellular matrix (ECM) is composed of many kinds of glycoproteins containing glycosaminoglycans (GAGs) moiety. The research was conducted based on the N-Acetylgalactosamine (GalNAc) degradation of ECM components by α-N-acetylgalactosaminidase (Nagalase) which facilitates migration...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ehsan Saburi, Jalil Tavakolafshari, Yousef Mortazavi, Alireza Biglari, Seyed Abbas Mirzaei, Samad Nadri
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Mashhad University of Medical Sciences 2017-09-01
Schriftenreihe:	Iranian Journal of Basic Medical Sciences
Schlagworte:	Alpha-N-Acetylgalactosamini dase Cancer Extracellular matrix Invasion Migration shRNA
Online-Zugang:	http://ijbms.mums.ac.ir/article_9271_452a27516d93e28ba9d3c97acf8e767c.pdf
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