Rational design of monomeric IL37 variants guided by stability and dynamical analyses of IL37 dimers
IL37 plays important roles in the regulation of innate immunity and its oligomeric status is critical to these roles. In its monomeric state, IL37 can effectively inhibit the inflammatory response of IL18 by binding to IL18Rα, a capacity lost in its dimeric form, underlining the pivotal role of the...
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| Principais autores: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Association for the Advancement of Science (AAAS)
2024-12-01
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| 叢編: | Computational and Structural Biotechnology Journal |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S2001037024001247 |
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