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BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability

Abstract Background Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance genes explain less than 5% of the cases arising at early-onset (< 56 years) and/or with familial aggregation of the disease. Considering that BubR1 is an essentia...

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Автори: Maria P. Silva, Luísa T. Ferreira, Natércia F. Brás, Lurdes Torres, Andreia Brandão, Manuela Pinheiro, Marta Cardoso, Adriana Resende, Joana Vieira, Carlos Palmeira, Gabriela Martins, Miguel Silva, Carla Pinto, Ana Peixoto, João Silva, Rui Henrique, Sofia Maia, Helder Maiato, Manuel R. Teixeira, Paula Paulo
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2024-07-01
Серія:Journal of Biomedical Science
Предмети:
BUB1B
BubR1
Cancer predisposition
Premature chromatid separation
Chromosomal instability
Taxol response
Онлайн доступ:https://doi.org/10.1186/s12929-024-01056-z
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