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The mechanisms and clinical significance of CD8+ T cell exhaustion in anti-tumor immunity

CD8+ T cell exhaustion, a critical challenge in the immune response to cancer, is characterized by a profound decline in the functionality of effector CD8+ T cells. This state of exhaustion is accompanied by the upregulation of various inhibitory receptors and significant shifts in both transcriptio...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Tao Zhong, Shuo Sun, Mingsheng Zhao, Bin Zhang, Huabao Xiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: China Anti-Cancer Association 2025-05-01
Schriftenreihe:Cancer Biology & Medicine
Schlagworte:
Online-Zugang:https://www.cancerbiomed.org/content/22/5/460
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