Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-<i>c</i>]pyridine Scaffold

Two novel series of compounds based on the 4,5,6,7-tetrahydrothieno[2,3-<i>c</i>]pyridine and 4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene molecular skeleton, characterized by the presence of a 3′,4′,5′-trimethoxyanilino moiety and a cyano or an alkoxycarbonyl group at its 2- or 3-position, respective...

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Detalhes bibliográficos

Principais autores:	Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Barbara Cacciari, Jan Balzarini, Sandra Liekens, Ernest Hamel, Andrea Brancale, Salvatore Ferla, Stefano Manfredini, Matteo Zurlo, Alessia Finotti, Roberto Gambari
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-04-01
Colecção:	Molecules
Assuntos:	microtubules structure–activity relationship antiproliferative activity tubulin tetrahydrothieno[2,3-<i>c</i>]pyridine
Acesso em linha:	https://www.mdpi.com/1420-3049/25/7/1690
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