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A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism

Abstract Background Hypoxia signaling, especially the hypoxia inducible factor (HIF) pathway, is a major player in clear cell renal cell carcinoma (ccRCC), which is characterized by disorders in lipid and glycogen metabolism. However, the interaction between hypoxia and lipid metabolism in ccRCC pro...

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Principais autores: Ren Liu, Yuanfa Feng, Yulin Deng, Zhihao Zou, Jianheng Ye, Zhiduan Cai, Xuejin Zhu, Yingke Liang, Jianming Lu, Hui Zhang, Yong Luo, Zhaodong Han, Yangjia Zhuo, Qingling Xie, Chi Tin Hon, Yuxiang Liang, Chin-Lee Wu, Weide Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-06-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Hypoxia
ccRCC
Metabolism
HIF1α
GPD1
Acesso em linha:https://doi.org/10.1186/s13046-021-01996-6
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