Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard in vitro antimicrobial susceptibility testing conditions. A novel phenotype among MRSA, termed “NaHCO3 responsiveness,” where certain st...

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Hauptverfasser:	Selvi C. Ersoy, Barbara Gonçalves, Gonçalo Cavaco, Adhar C. Manna, Rita G. Sobral, Cynthia C. Nast, Richard A. Proctor, Henry F. Chambers, Ambrose Cheung, Arnold S. Bayer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2022-12-01
Schriftenreihe:	Microbiology Spectrum
Schlagworte:	methicillin-resistant Staphylococcus aureus (MRSA) sodium bicarbonate penicillin-binding proteins (PBPs) peptidoglycan (PG) wall teichoic acid (WTA) β-lactams
Online-Zugang:	https://journals.asm.org/doi/10.1128/spectrum.03422-22
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