Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor

Inhibition of &#946;-lactamases presents a promising strategy to restore the &#946;-lactams antibacterial activity to resistant bacteria. In this work, we found that aromatic carboxyl substituted 2-triazolylthioacetamides <b>1a</b>&#8722;<b>j</b> inhibited VIM-2, exhibiting an IC₅₀ value...

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Váldodahkkit:	Yang Xiang, Yue-Juan Zhang, Ying Ge, Yajun Zhou, Cheng Chen, Weixiao Yuan Wahlgren, Xiangshi Tan, Xi Chen, Ke-Wu Yang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2020-01-01
Ráidu:	Biomolecules
Fáttát:	antibiotic resistance metallo-β-lactamase vim-2 inhibitor 2-triazolylthioacetamides thermodynamics crystallographic study
Liŋkkat:	https://www.mdpi.com/2218-273X/10/1/72
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