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A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock

INTRODUCTION: Combining the hemodynamic and immune benefits of hypertonic saline with the anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline (HSPTX) as a hemorrhagic shock resuscitation strategy reduces lung injury when compared with the effects of Ringer's lactate (RL). We...

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Main Authors: Todd W. Costantini, Jessica Deree, J.O. Martins, James G. Putnam, Tercio de Campos, Raul Coimbra
Format: Artigo
Language:Inglês
Published: Elsevier España 2010-01-01
Series:Clinics
Subjects:
Hypertonic saline
Pentoxifylline
NF-κB
CREB
CREB-binding protein
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000600010
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