Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging

Oxidative stress is a hallmark of metabolic disease, though the mechanisms that define this link are not fully understood. Irreversible modification of proteins by reactive lipid aldehydes (protein carbonylation) is a major consequence of oxidative stress in adipose tissue and the substrates and spe...

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Auteurs principaux:	Amy K. Hauck, Tong Zhou, Ambuj Upadhyay, Yuxiang Sun, Michael B. O’Connor, Yue Chen, David A. Bernlohr
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2020-12-01
Collection:	Antioxidants
Sujets:	histone carbonylation adipose epigenomics 4-HNE (4-hydroxynonenal) 4-HHE (4-hydroxy hexenal)
Accès en ligne:	https://www.mdpi.com/2076-3921/9/12/1210
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