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A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial

Abstract Each amino acid except two is encoded by multiple synonymous codons, but at unequal frequencies. Such codon usage bias (CUB) is observable in almost all species, and commonly assumed as the result of natural selection towards an optimal CUB that matches the cellular tRNA supply. Here we hyp...

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Detalhes bibliográficos
Principais autores: Feng Chen, Yao Liu, Ziwei Zhou, Jia Liao, Xinran Fan, Yanying Huang, Yifei Chen, Jingyu Chen, Jian-Rong Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-02-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-026-69643-2
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