A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <italic toggle="yes">Salmonella</italic> Infection

ABSTRACT A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, C...

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Detalhes bibliográficos

Principais autores:	Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2019-10-01
Colecção:	mBio
Assuntos:	CRISPR Salmonella bacteria genome-wide screen macrophages
Acesso em linha:	https://journals.asm.org/doi/10.1128/mBio.02169-19
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