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The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis

Abstract Epigenetic mechanisms are crucial for neocortical development. Recent work has highlighted that ablation of Setd2, which encodes a SET domain lysine methyltransferase, from the mouse dorsal telencephalon results in deficits in reciprocal cortico-thalamic connectivity. However, analysis of b...

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Detalles Bibliográficos
Principais autores: Cooper Atterton, Hallie Naumann, Benjamin Mitchell, Bee Meibusch, Laura Currey, Nyoman D. Kurniawan, Stefan Thor, Michael Piper
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-09-01
Series:Scientific Reports
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Acceso en liña:https://doi.org/10.1038/s41598-025-18780-7
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