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Processing-induced changes in neuroprotective components and mechanisms of gardeniae fructus: integrating UPLC-Q-TOF-MS/MS, network pharmacology, and in vitro analysis

Abstract Objective Gardeniae Fructus (GF), the dried fruit of Gardenia jasminoides J. Ellis, has been used in East Asian medicine for centuries. Its carbonized form, Gardeniae Fructus Carbonisatus (GFC), is produced through processing, yet the effects of this transformation on active constituents an...

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Main Authors: Le Sun, Ziyu Hou, Wenjie Wang, Peiling Wu, Pei Ma, Jiali Huang, Leyang Fan, Lijia Xu, Haibo Liu, Peigen Xiao
Format: Artigo
Language:Inglês
Published: SpringerOpen 2026-01-01
Series:Bioresources and Bioprocessing
Subjects:
Gardeniae fructus
Gardeniae fructus carbonisatus
Geniposide
Crocetin
Neuroinflammation
Ferroptosis
Online Access:https://doi.org/10.1186/s40643-025-01005-0
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