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Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhythmic substrate has been hypothesised to be amenable to late Na+ block with ranolazine, the specific mechanisms are not fully understood. Therefore, this study aimed to investigat...

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Principais autores: James A. Coleman, Ruben Doste, Matteo Beltrami, Alessia Argirò, Raffaele Coppini, Iacopo Olivotto, Betty Raman, Alfonso Bueno-Orovio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Pharmacology
Fag:
hypertrophic cardiomyopathy
ranolazine
drug safety and efficacy
arrhythmic risk
modelling and simulation
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1379236/full
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