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Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells

Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and immune-mediated neurotoxicity, but the molecular mechanisms of αSynAgg-induced immune activation are poorly defined. We performed quantitative proteomics...

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Kaydedildi:
Asıl Yazarlar: Souvarish Sarkar, Eric B. Dammer, Emir Malovic, Abby L. Olsen, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Danielle L. Oliver, Duc Duong, Valerie Joers, Nicholas Seyfried, Meixiang Huang, Thomas Kukar, Malú G. Tansey, Anumantha G. Kanthasamy, Srikant Rangaraju
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020-01-01
Seri Bilgileri:Frontiers in Immunology
Konular:
synuclein
microglia
neuroinflammation
Parkinson's disease
proteomics
Online Erişim:https://www.frontiersin.org/article/10.3389/fimmu.2020.00033/full
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