ITK overexpression enhances T cell cytotoxicity against DLBCL through the TCR-Ca2+-Calcineurin-NFAT-IFN-γ pathway

Abstract Diffuse Large B-Cell Lymphoma (DLBCL) is the most prevalent pathological subtype of non-Hodgkin lymphoma (NHL). Patients with DLBCL often experience extremely poor prognoses due to drug resistance or relapse, and the limitations of existing treatment regimens are evident. This study focuses...

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Bibliografische gegevens

Hoofdauteurs:	Huifang Liu, Mengyang Zhang, Xianguang Zhu, Guanghui Chen
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Portfolio 2025-08-01
Reeks:	Scientific Reports
Onderwerpen:	Diffuse large B-cell lymphoma, ITK TCR signaling pathway Immune microenvironment Rituximab
Online toegang:	https://doi.org/10.1038/s41598-025-16112-3
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