Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats

Abstract Polyacrylic acids are widely used in industrial and consumer products, yet increasing evidence indicates that they can induce severe lung injury and rapidly progressing fibrosis. The underlying mechanisms remain unclear. In this study, we investigated the pulmonary toxicity of polyacrylic a...

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Detalhes bibliográficos

Principais autores:	Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Shinya Morimoto, Toshiki Morimoto, Yasuyuki Higashi, Hidenori Higashi, Midori Iida, Takuma Kojima, Kazuo Sakurai, Akihiro Moriyama, Jun-ichi Takeshita, Kazuhiro Yatera, Yasuo Morimoto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-12-01
coleção:	Scientific Reports
Assuntos:	Polyacrylic acid Polyethylene glycol Intratracheal instillation Metabolomics Fibrosis Rat
Acesso em linha:	https://doi.org/10.1038/s41598-025-33213-1
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