Acceleration of the Deamination of Cytosine through Photo-Crosslinking

Herein, we report the major factor for deamination reaction rate acceleration, i.e., hydrophilicity, by using various 5-substituted target cytosines and by carrying out deamination at high temperatures. Through substitution of the groups at the 5′-position of the cytosine, the effect of hydrophilici...

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Bibliographic Details

Main Authors:	Siddhant Sethi, Yasuharu Takashima, Shigetaka Nakamura, Licheng Wan, Nozomi Honda, Kenzo Fujimoto
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2023-05-01
Series:	Current Issues in Molecular Biology
Subjects:	DNA manipulation cytosine deamination photo-crosslinking nucleobase editing RNA editing
Online Access:	https://www.mdpi.com/1467-3045/45/6/298
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