C-terminal binding protein-2 triggers CYR61-induced metastatic dissemination of osteosarcoma in a non-hypoxic microenvironment

Abstract Background Osteosarcoma is the most prevalent cancer-related bone disease diagnosed in the pediatric age group. The rapid development of metastatic lesions and resistance to chemotherapy remain major mechanisms responsible for the failure of treatments and poor outcome. We established that...

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Hauptverfasser:	Laura Di Patria, Nadia Habel, Robert Olaso, Romain Fernandes, Catherine Brenner, Bojana Stefanovska, Olivia Fromigue
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-03-01
Schriftenreihe:	Journal of Experimental & Clinical Cancer Research
Schlagworte:	Cysteine-rich angiogenic protein 61 C-terminal Binding Protein Hypoxia Metastasis Invasion Bone tumor
Online-Zugang:	https://doi.org/10.1186/s13046-025-03350-6
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