Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration

Background Huntington’s disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expec...

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Principais autores:	Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	PeerJ Inc. 2017-04-01
סדרה:	PeerJ
נושאים:	Riluzole Neurodegeneration Huntington’s disease Transgenic models Neurogenesis Neuroprotection
גישה מקוונת:	https://peerj.com/articles/3240.pdf
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